The ambiguity and limit of caffeine in migraine: a literature review

Introduction Migraine is a chronic disease that affects about 15% of world's population. It the most disabling among men and women under 50 years. Studies indicate caffeine, which consumed stimulating in world present on daily diet, can be related to migraine an ambiguous way. ObjectiveConsidering epidemiologic economic point view, phisiopatology accessibility this study aims understand if there would safe minimum dosage caffeine for patients with migraine. MethodsThe words "migraine" "caffeine" were searched July 2022 at PUBMED BVS predetermined filters selection publication qualis journals A1 A2. 13 articles found revision. ResultsCaffeine's effects nervous system its relation headaches have been target several studies, mainly producing symptoms similars prodromic phase e existence Caffeine Abstinence Syndrome, known as diagnostic entity by International Classification. The sensory hypersensitivity (migraine's characteristic) does not appear abstinence syndrome. lack information pre-existing headache studies shows gap parameter ''caffeine withdrawal trigger per se''. possible premonitory such yawns, low energy sleepiness lead intake, bringing forth wrong idea it has initiated migraine.Caffeine, however, induces urinary magnesium loss, reducing reabsorption. As neuromuscular conduction, nerve transmission beneficial pain conditions migraines, decreasing level, induce headache. Additionally, contains thiaminases, enzymes degrade thiamine, may protective potential (To see complete abstract, please, check out PDF).